When symptoms occur, they can be local or generalized. Local symptoms include painful or frequent urination, a sudden decrease in the size and force of the urinary stream or blood in the urine. Generalized symptoms relate to spread to bone and include pain in the back, hips, thighs or shoulders. There is weight loss and fatigue as the tumor progresses. Prostate cancer is seldom curable once symptoms develop, which is the best argument for early detection through screening .
